This is the first meeting between these two clubs since the 2014 FA Cup semi-final, when Arsenal won on penalties and Mikel Arteta scored in a shootout. The Gunners went on to beat Hull City in the final.
Things have changed a lot for Wigan since then and not in a good way.
They have just sacked their manager Ryan Lowe after sliding into the League One relegation zone and it's hard to see them forcing a shootout this time, no matter how many changes Arteta makes.
Arsenal have not had much joy in the FA Cup since Arteta won it again as manager in 2019-20, a few months after taking charge.
They have not been past round four since, but they are going to make it to the last 16 this time, I'm sure of it.
In fact, they have got so much strength in depth now that, while for years Arteta has not been able to win anything at all, he could feasibly win four trophies this season.
Is the quadruple on? That could be the question we are asking in the final few months of the season.
Sutton's prediction: 3-0
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