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The Crosstown Classic takes center stage as the Chicago White Sox visit the Chicago Cubs at Wrigley Field, with both teams in playoff position. Shota Imanaga takes the mound for the Cubs against the White Sox. milkshake.it.com

Other notable matchups include the Arizona Diamondbacks visiting the Boston Red Sox, the Los Angeles Dodgers traveling to Coors Field to face the Colorado Rockies, and the San Diego Padres visiting the New York Mets with Walker Buehler getting the start for San Diego.