Liverpool enter the tie after a mixed run, highlighted by a 6‑0 win over Qarabag but losses to Manchester City and Bournemouth. Key defender Wataru Endo is ruled out, while Joe Gomez may start and Dominik Szoboszlai returns from suspension.
Brighton arrive in a slump, having won only two of 15 matches and facing scrutiny over coach Fabian Hurzeler. The Seagulls will look to reverse fortunes in front of a hostile Anfield crowd.