Trey Green and Ishan Sharma each scored 14 points to lead the Billikens (24-1, 12-0 Atlantic 10), who matched the 2013-14 team for the best A10 start in school history. Quentin Jones added 12 points, and Amari McCottry had 11 for Saint Louis.
The Billikens pulled away midway through the second half and now hold a two-game lead over Virginia Commonwealth in the A10 with six games remaining. Loyola (6-20, 2-11) received 12 points from Justin Moore and a career-high 11 from Daniil Glazkov.