The 26-year-old was forced off in the closing stages of the match, raising immediate concerns for the club's title charge.
Initial reports suggest the issue could keep him out for months, dealing a significant blow to Eddie Howe's squad.
Bruno Guimaraes facing months out with hamstring injury
Newcastle United midfielder Bruno Guimaraes is facing a spell on the sidelines after suffering a hamstring injury during Tuesday's victory over Tottenham.